Philip N Hawkins Selected Research

Serum Amyloid P-Component

1/2018	Repeat doses of antibody to serum amyloid P component clear amyloid deposits in patients with systemic amyloidosis.
9/2015	Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component.
6/2013	Monitoring systemic amyloidosis using MRI measurements of the extracellular volume fraction.
10/2012	Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use.
11/2010	Antibodies to human serum amyloid P component eliminate visceral amyloid deposits.
3/2010	Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosis.
5/2009	Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component.
4/2006	Diagnostic performance of 123I-labeled serum amyloid P component scintigraphy in patients with amyloidosis.
9/2005	Quantitative high-resolution microradiographic imaging of amyloid deposits in a novel murine model of AA amyloidosis.
1/2003	Novel pharmacological strategies in amyloidosis.

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Philip N Hawkins Research Topics

Disease

120	Amyloidosis 05/2022 - 06/2002
64	Immunoglobulin Light-chain Amyloidosis 01/2022 - 05/2003
30	Amyloid Plaque 12/2021 - 10/2002
15	Cardiomyopathies (Cardiomyopathy) 01/2022 - 03/2004
13	Transthyretin-Related Hereditary Amyloidosis 12/2021 - 06/2005
13	Inflammation (Inflammations) 09/2017 - 02/2004
11	Chronic Kidney Failure (Chronic Renal Failure) 05/2022 - 11/2005
11	Cryopyrin-Associated Periodic Syndromes 01/2021 - 09/2002
9	Proteinuria 01/2020 - 10/2002
8	Renal Insufficiency (Renal Failure) 01/2020 - 03/2004
7	Familial Amyloidosis (Hereditary Amyloidosis) 05/2017 - 05/2003
6	Aortic Valve Stenosis (Aortic Stenosis) 01/2022 - 04/2013
6	Paraproteinemias (Monoclonal Gammopathy) 01/2021 - 07/2003
6	Fever (Fevers) 02/2013 - 09/2002
5	Infections 05/2022 - 01/2009
5	Polyneuropathies (Polyneuropathy) 06/2021 - 03/2004
5	Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy) 01/2020 - 10/2004
4	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 04/2006
4	autosomal dominant familial Periodic fever 01/2011 - 01/2002
3	Hypertrophy 01/2021 - 03/2015
3	Disease Progression 09/2018 - 06/2013
3	Body Weight (Weight, Body) 01/2018 - 08/2006
3	Necrosis 12/2012 - 04/2006
2	Bundle-Branch Block (Fascicular Block) 01/2021 - 10/2020
2	Restrictive Cardiomyopathy 01/2020 - 01/2018
2	Schnitzler Syndrome 01/2018 - 02/2013
2	Rare Diseases (Rare Disease) 06/2016 - 09/2013
2	Nephrotic Syndrome (Syndrome, Nephrotic) 06/2014 - 12/2006
2	Cardiovascular Diseases (Cardiovascular Disease) 02/2014 - 04/2006
2	Infarction (Infarctions) 09/2013 - 04/2006
2	Myocardial Infarction 09/2013 - 04/2006
2	Acute-Phase Reaction 10/2012 - 11/2005
2	Heart Diseases (Heart Disease) 10/2012 - 10/2004
2	Stroke (Strokes) 11/2010 - 04/2006
2	Familial Mediterranean Fever (Periodic Disease) 01/2009 - 06/2007
2	Exanthema (Rash) 12/2006 - 08/2006

Drug/Important Bio-Agent (IBA)

91	Amyloid (Amyloid Fibrils)IBA 01/2022 - 06/2002
50	Prealbumin (Transthyretin)IBA 01/2022 - 06/2002
30	Proteins (Proteins, Gene)FDA Link 05/2022 - 01/2003
16	AA amyloidosisIBA 01/2021 - 09/2002
11	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2012
11	Serum Amyloid P-ComponentIBA 01/2018 - 11/2002
10	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 01/2022 - 07/2003
10	Bortezomib (Velcade)FDA Link 04/2021 - 02/2008
10	GadoliniumIBA 01/2020 - 11/2008
10	Fibrinogen (Factor I)FDA Link 07/2019 - 06/2002
9	Blood Proteins (Serum Proteins)IBA 12/2021 - 11/2002
8	Pharmaceutical PreparationsIBA 01/2018 - 05/2006
8	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2018 - 02/2004
6	Apolipoprotein A-I (Apolipoprotein A1)IBA 05/2022 - 06/2002
6	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2022 - 11/2007
6	canakinumab FDA Link 01/2021 - 06/2009
6	Serum Amyloid A Protein (Serum Amyloid A)IBA 01/2020 - 11/2005
6	Dexamethasone (Maxidex)FDA LinkGeneric 01/2020 - 01/2007
6	AntibodiesIBA 01/2019 - 11/2005
5	CreatinineIBA 05/2022 - 06/2007
5	AcidsIBA 01/2022 - 11/2014
5	Interleukin-1 (Interleukin 1)IBA 07/2019 - 02/2004
5	pyrrolidineIBA 01/2018 - 05/2009
5	Carboxylic AcidsIBA 01/2018 - 05/2009
5	C-Reactive ProteinIBA 02/2014 - 11/2005
5	DNA (Deoxyribonucleic Acid)IBA 02/2013 - 01/2002
4	pro-brain natriuretic peptide (1-76)IBA 01/2022 - 04/2013
4	patisiranIBA 12/2021 - 08/2013
3	InterleukinsIBA 01/2021 - 12/2006
3	Immunoglobulin M (IgM)IBA 01/2018 - 11/2008
3	Complement System Proteins (Complement)IBA 09/2015 - 04/2006
3	Doxycycline (Periostat)FDA LinkGeneric 01/2015 - 06/2013
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 09/2014 - 01/2007
3	Thalidomide (Thalomid)FDA Link 09/2014 - 01/2007
3	Type I Tumor Necrosis Factor ReceptorsIBA 12/2012 - 01/2002
3	Proline (L-Proline)FDA Link 11/2010 - 05/2009
3	Interleukin-1beta (Interleukin 1 beta)IBA 05/2009 - 06/2006
2	Diflunisal (Dolobid)FDA Link 12/2021 - 01/2015
2	Troponin T (Troponin T1)IBA 01/2021 - 01/2013
2	Monoclonal AntibodiesIBA 01/2021 - 05/2012
2	Colchicine FDA LinkGeneric 01/2021 - 11/2007
2	revusiranIBA 12/2020 - 01/2020
2	Lenalidomide (CC 5013)FDA Link 01/2020 - 09/2014
2	Congo RedIBA 01/2019 - 06/2017
2	CytokinesIBA 01/2018 - 01/2011
2	miridesapIBA 01/2018 - 01/2018
2	AntigensIBA 01/2017 - 06/2006
2	ParaproteinsIBA 10/2016 - 02/2006
2	RNA (Ribonucleic Acid)IBA 06/2016 - 05/2012
2	GelsolinIBA 12/2014 - 06/2014
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2011 - 01/2008
2	Melphalan (Alkeran)FDA LinkGeneric 11/2007 - 01/2007
2	fibrinogen AalphaIBA 03/2007 - 11/2005

Therapy/Procedure

33	Therapeutics 01/2022 - 11/2002
16	Drug Therapy (Chemotherapy) 01/2021 - 07/2003
7	Stem Cell Transplantation 04/2021 - 02/2006
7	Liver Transplantation 01/2015 - 03/2004
5	Kidney Transplantation 01/2021 - 12/2006
4	Transplantation 05/2022 - 03/2007
4	Lasers (Laser) 05/2017 - 10/2011
3	Transcatheter Aortic Valve Replacement 01/2022 - 01/2018
2	RNAi Therapeutics 01/2018 - 08/2013
2	Injections 01/2017 - 08/2006
2	Heart Transplantation (Grafting, Heart) 02/2006 - 10/2004